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KMID : 0352720210450050546
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Journal of Ginseng Research
2021 Volume.45 No. 5 p.546 ~ p.554
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Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: A randomized controlled trial
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Jovanovski Elena
Smircic-Duvnjak Lea
Komishon Allison
Fei Rodney Au-Yeung
Sievenpiper John L.
Zurbau Andreea
Jenkins Alexandra L.
Sung Mi-Kyung
Josse Robert
Li Dandan
Vuksan Vladimir
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Abstract
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Background: Diabetes mellitus and hypertension often occur together, amplifying cardiovascular disease (CVD) risk and emphasizing the need for a multitargeted treatment approach. American ginseng (AG) and Korean Red Ginseng (KRG) species could improve glycemic control via complementary mechanisms. Additionally, a KRG-inherent component, ginsenoside Rg3, may moderate blood pressure (BP). Our objective was to investigate the therapeutic potential of coadministration of Rg3-enriched Korean Red Ginseng (Rg3-KRG) and AG, added to standard of care therapy, in the management of hypertension and cardiometabolic risk factors in type-2 diabetes.
Methods: Within a randomized controlled, parallel design of 80 participants with type-2 diabetes (HbA1c: 6.5?8%) and hypertension (systolic BP: 140?160 mmHg or treated), supplementation with either 2.25 g/day of combined Rg3-KRG + AG or wheat-bran control was assessed over a 12-wk intervention period. The primary endpoint was ambulatory 24-h systolic BP. Additional endpoints included further hemodynamic assessment, glycemic control, plasma lipids and safety monitoring.
Results: Combined ginseng intervention generated a mean ± SE decrease in primary endpoint of 24-h systolic BP (?3.98 ± 2.0 mmHg, p = 0.04). Additionally, there was a greater reduction in HbA1c (?0.35 ± 0.1% [?3.8 ± 1.1 mmol/mol], p = 0.02), and change in blood lipids: total cholesterol (?0.50 ± 0.2 mmol/l, p = 0.01), non-HDL-C (?0.54 ± 0.2 mmol/l, p = 0.01), triglycerides (?0.40 ± 0.2 mmol/l, p = 0.02) and LDL-C (?0.35 ± 0.2 mmol/l, p = 0.06) at 12 wks, relative to control. No adverse safety outcomes were observed.
Conclusion: Coadministration of Rg3-KRG + AG is an effective addon for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes.
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KEYWORD
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Ginseng, Hypertension, Randomized controlled trial, Type-2 diabetes
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